A recent paper entitled “Multifactorial causal model of brain (dis)organization and therapeutic intervention: Application to Alzheimer’s disease” by Dr. Yasser Iturria-Medina and colleagues of the MCIN was published in Science Direct.
In this article, we focus on describing the model and applying it at the population-based level for studying late onset Alzheimer’s disease (LOAD). By interrelating six different neuroimaging modalities and cognitive measurements, this model accurately predicts spatiotemporal alterations in brain amyloid-β (Aβ) burden, glucose metabolism, vascular flow, resting state functional activity, structural properties, and cognitive integrity. The results suggest that a vascular dysregulation may be the most-likely initial pathologic event leading to LOAD.
- A multifactorial causal model (MCM) of brain (dis)organization and therapeutic intervention is proposed.
- Prediction of complex multifactorial alterations in Alzheimer’s disease, using six different neuroimaging modalities and the MCM.
- Identification of potential triggering pathological events and associated “epicenter” brain regions.
- Identification and characterization of direct multifactorial interactions, vulnerability, and influence level of each biological factor.
- Identification of optimum therapeutic strategies to stop/reverse disease.
Read the full paper HERE
The research done at the MCIN was mentioned as the 12th top story of 2016.
The story entitled “Big Data May Lead to Earlier Alzheimer’s Diagnosis: A new algorithm charts a 30-year trajectory for biological risk factors” by Linda Marsa describes the technique developed at the MCIN that may detect Alzheimers in its earliest stages.
The full article can be seen here.
The Montreal Neurological Institute is hoping to change the way discoveries are made with the help of a multi-million dollar donation.
Larry Tanenbaum and his wife Judy are giving $20 million to create the Tanenbaum Open Science Institute, which will collect and make available research on neurological diseases.
The official announcement was made Friday in conjunction with McGill University, which is affiliated with the institute, and Prime Minister Justin Trudeau.
Modeled after the idea of open source software, the institute will also keep the research patent-free and make its findings freely accessible worldwide.
The approach is meant to speed up the time it takes for research to translate into treatment for patients.
“Our goal is simple: to accelerate brain research and discovery to relieve suffering,” said Tanenbaum.
– Caption from cbc.ca. Read the full article here
‟Today, we take an important step forward in opening up new horizons in neuroscience research and discovery,” said Mr. Larry Tanenbaum. ‟Our digital world provides for unprecedented opportunities to leverage advances in technology to the benefit of science. That is what we are celebrating here today: the transformation of research, the removal of barriers, the breaking of silos and, most of all, the courage of researchers to put patients and progress ahead of all other considerations.”
– Caption from McGill Newsroom. Read the full article here
Highlights from the opening of the event held at the MNI included:
- A Presentation from Yale University Professor of Psychiatry & Psychology David Glahn, PhD, entitled Localizing Genetic Loci for Affective and Psychotic Disorders with Endophenotypes Mechanisms and Molecules.
- A Presentation from David Kennedy, PhD, from the Department of Psychiatry of the University of Massachusetts Medical Center entitled Advancing Reproducibility in Neuroimaging Computation the ReproNim Concepts.
On Nov 29th, Dr. Low, CEO of NeuroVigil spoke to the MNI on about various topics including the SPEARS algorithm for measuring sleep patterns, and the iBrain device allows researchers to conduct studies with minimal setup and provides patients with a less-intrusive experience. Additionally, Dr. Low spoke about an initiative to build a Canadian NeuroZone.
Link to NeuroVigil website here
The Principal of McGill, Dr. Suzanne Fortier and the Principal’s International Advisory Board visited MCIN on Tuesday November 15. Presentations by Drs. Edward Fon, Michael Meaney and Penelope Kostopoulos described the open science initiatives at the MNI and the role of the Ludmer Centre and MCIN more specifically in the Healthy Brain Healthy Lifes project and other international neuroscience initiatives.
Video Source Here
By Kathryn Jezer-Morton
Yesterday, the Government of Quebec bestowed its highest citation for accomplishments in cultural and scientific fields, the Prix du Québec, on two McGill researchers. Prof. John A. Hall of the Department of Sociology, Faculty of Arts received the Prix Léon-Gérin for human and social sciences, and Prof. Alan Evans received the Wilder-Penfield prize for biomedical research. A total of 14 Prix du Québec laureates were named this year. The Prix have been awarded every year since 1977.
Prof. Alan Evans is James McGill Professor of Neurology, Psychiatry and Biomedical Engineering at McGill, and a principal investigator and former head of The Montreal Neurological Institute’s McConnell Brain Imaging Centre (BIC), where Canada’s first PET scans, MR images and CT scans were produced. After earning his PhD in biophysics at the University of Leeds (UK), he worked for five years at Atomic Energy of Canada before joining The Neuro in 1984.
Prof. Evans studies functional neuroanatomy by using three-dimensional computer techniques linked to advanced brain imaging scans (PET and MRI). His work in collaboration with cognitive neuroscientists has led to the creation of important brain structural models and large-scale brain databases. Since 2008 he has directed the CBRAIN program, a research platform for neuroinformatics that has formed the basis for the Big Brain project, a highly detailed open-access brain imaging database that provides imaging details down to the cellular level.
He is also the Scientific Director of the newly launched Healthy Brains for Healthy Livesprogram, funded by a seven-year, $84 million award from the Canada First Research Excellence Fund. Healthy Brains for Healthy Lives is a cross-disciplinary initiative to advance the understanding of the human brain with the goal of making long-term improvements in clinical outcomes of the treatment of brain diseases and disorders.
Prof. John A. Hall the James McGill Professor of Comparative Historical Sociology. His work in sociology deals with state-building and nation-building, with an emphasis on European history. His recent research looks into the ways in which Ireland, Denmark and Switzerland – all three small, relatively homogenous nation-states – managed the 2008 financial crisis. A book on the topic, The Paradox of Vulnerability, is currently in press. He is the author of over thirty books and has authored or co-authored over sixty book chapters and scholarly articles in the field of political sociology.
Prof. Hall’s citation for the Prix du Quebec states that his interdisciplinary work in sociology and history sets him apart as one of the finest observers of contemporary political realities. Earlier this year, Prof. Hall was honoured by the Royal Society of Canada with the Innis-Gérin Medal for his distinguished and sustained contribution to the literature of the social sciences.
“McGill takes great pride in the career accomplishments of Prof. Hall and Prof. Evans. Thanks to the Prix du Quebec for recognizing their respective contributions to developing understanding in the political trajectories of nation-states, and the mapping and analysis of the human brain,” said Rosie Goldstein, Vice-Principal (Research and Innovation.)
The purpose of the Prix du Quebec is to recognize the career of women and men who have demonstrated a passion for their calling. Winners are individuals who have stood out for their creative or innovative spirit and whose work has contributed to the influence of Quebec around the world and to the evolution of Québec society in their respective fields.
See the original article here
On Nov 4th, the MCIN hosted a Hackathon at Hurley’s Pub. Good food and great company inspired new ideas and collaborations amongst those in attendance.