As part of the The Feindel Brain Imaging Lecture Series, Dr Yasser Iturria Medina presented “Towards a Multifactorial Characterization of Neurodegeneration”. The slideshow from the presentation can be viewed here [Google Slides]
Montreal Neurological Institute
Yasser Iturria Medina (Havana, 1980), has a Nuclear Engineering background, a Master’s degree in Neurophysics and a PhD in Health Sciences. In 2003, he joined the Cuban Neuroscience Center, pioneering initial attempts to map/characterize whole brain connectivity patterns using diffusion tractography techniques. His current work is mainly focused on the development and validation of multifactorial association models of brain (dis)organization and cognition, which a particular emphasis on neurodegenerative mechanisms. At the present, he is a Banting postdoctoral fellow at MNI.
Some relevant references for the talk:
- Yasser Iturria-Medina et al., 2016. Early Role of Vascular Dysregulation on Late-Onset Alzheimer´s Disease Progression: evidence from a multi-factorial data-driven analysis. Nature Communications, 7, # 11934, doi:10.1038/ncomms11934.
- Yasser Iturria-Medina and Alan C. Evans, 2015. On the central role of brain connectivity in neurodegenerative disease progression. Frontiers in Aging Neuroscience. Review paper. May, vol 7, article 90. DOI: 10.3389/fnagi.2015.00090.
- Yasser Iturria-Medina et al., 2014. Epidemic Spreading Model to Characterize Misfolded Proteins Propagation in Aging and Associated Neurodegenerative Disorders. PLOS Computational Biology, Vol. 10 (11), e1003956.
The Montreal Alzheimer Research for a Cure (MARC) initiative and website were recently featured on several television networks as part of World Alzheimer’s Day. The founder of MARC, Dorothy Reitman of the Reitman Family Foundation, was interviewed for a segment on CTV. In addition, Jacob Vogel of the MCIN lab was also interviewed to provide a scientific background to the work.
Published Wednesday, September 21, 2016 10:08PM EDT
Wednesday marked World Alzheimer’s Day, a disease that some Montrealers believe local researchers will soon be able to stamp out.
Among the disease’s casualties was Cyril Reitman, a Montrealer well known for the clothing store that bears his name.
“It was horrendous to see this man decline,” said Reitman’s widow, Dorothy. “It just broke my heart to watch this, and as it happened, I decided it must never happen again. We must prevent this.”
Dorothy Reitman is now the driving force behind a fundraising campaign aimed at helping Montreal-based scientists to find a cure.
Among those researchers is Jacob Vogel of McGill University’s integrative program in neuroscience. He works in Dr. Alan Evan’s lab, which specializes in brain imaging, or the mapping and rendering of how the brain works.
Près de 35 millions de personnes sont atteintes de la maladie d’Alzheimer dans le monde. La journée mondiale qui lui est consacrée le 21 septembre est l’occasion de faire le point sur les différentes recherches en cours et notamment celles effectuées à Montréal.
La docteure Andréa C. Leblanc travaille depuis plus de 25 ans à la découverte d’un médicament pour endiguer cette maladie dégénérative.
Marc-Fund.ca engages the younger generation in the fight against Alzheimer’s disease and dementia
The first online fundraising program dedicated exclusively to supporting Montreal-based research into the early detection and treatment of Alzheimer’s disease and related dementia was launched on Sept. 12.
By McGill Reporter Staff
This morning, Thursday, September 15, 2016, the Canada Foundation for Innovation announced that it will invest more than $1.1 million in CBRAIN, one of the world’s most advanced computing platforms for brain research. Marc Miller, Member of Parliament for Ville-Marie — Le Sud-ouest — Île-des-sœurs, made the announcement at McGill on behalf of the Honourable Kirsty Duncan, the Minister of Science.
The CBRAIN investment is one of seven projects, across six universities, to receive funding under CFI’s new Cyberinfrastructure Initiative.
McGill has been successful in the national competition for a massive amount of research funding under the federal government’s Canada First Excellence Research Fund (CFREF), which will provide the University with an $84-million grant over seven years to support an ambitious effort in neuroscience to advance understanding of the human brain and ease the burden of neurological and mental-health disorders.
By McGill reporter staff
$ 900 million for universities
Ottawa invests almost a billion dollars in to research for major Canadian universities.
Support from the Canada First Research Excellence Fund (CFREF)
- $84 million in federal funding over seven years
- $150 million for Canadian neuroscience via CFREF projects at McGill (HBHL) and Western ($66 million for “Beautiful minds: Brain health for life”)
- $213.2 million for three complementary Montreal projects at McGill, Université de Montréal, and Polytechnique Montréal
- Financial support for innovation from the Government of Quebec
- More than $50 million in philanthropic gifts already committed
- 3 partners on a new pan-Canadian Network for Brain Health: Western University, Brain Canada, and Canadian Institute for Advanced Research (CIFAR)
- 19 academic institutions
- 12 foundations
- 9 industry partners
- 7 Canadian consortia
- 5 international consortia
- BigBrain Project
- European Human Brain Project
- Human Connectome Project
- Organisation for Economic Co-operation and Development (OECD)
- Organisation of Human Brain Mapping
- 4 incubators
- 3 venture capitalists
- 3 research networks
- 1 research commercialization agent
Building on world-class resources
- Inaugural Scientific Director: Alan C. Evans, who is in the top 1% of highly cited researchers in the world
- McGill Neuroscience brings together
- 250 scientists and clinicians
- 1,300 graduate students
- 255 postdoctoral fellows
- $65 million annually in research funding
- Affiliated hospitals, research institutes, and basic research departments
- Montreal Neurological Institute and Hospital
- McGill Centre for Research in Neuroscience
- Douglas Mental Health University Institute
- McGill University and Genome Quebec Innovation Centre
- Lady Davis Institute for Medical Research
- Ludmer Centre for Neuroinformatics and Mental Health
- McGill University Health Centre Goals
- Understand the healthy brain
- Shed new light on how the brain wires itself
- Advance how we categorize disorders
- Develop new diagnostic tools
- Discover new ways to treat disease
- Improve patient access to novel treatments
- Translate knowledge into public health, workplace, or social interventions
How the funding will be spent
- Discovery Fund for Interdisciplinary Research
- Research Transition Awards
- Seed Award for Innovative Ideas
- Student and Postdoctoral Fellow Training Clusters
- New Investigators Start-up Grants
- Visiting Fellows
- International Collaboration Platform
- Neuro-Innovation Fund
- Knowledge Mobilization
- Technology Development
- Core Facilities Operations
Anticipated outcomes by 2023
- “Canadian Framework for Brain Health” launched
- $84 million in leveraged funds from external sources (1:1)
- 1,500 high-income jobs
- 30 spinoff companies and licensing contracts
- 10% increase of McGill faculty working in related areas
- 20% increase of McGill students and postdoctoral fellows working in related areas
During a recent visit to the Neuro, representatives from CGI experienced the Big Brain on their tour of the Ludmer Centre and the MCIN.
Delegates from China experienced the Big Brain during a tour of the MNI with Dr. Sandra McPherson (Interim Executive Director, External Affairs, MNI), Dr. Lan Xiong (Adjunct Professor, McGill University; and Coordinator of MNI-Shenzhen Project), and Kally Walsh (Associate Director, International Relations (interim), McGill University).
Earlier this year, Nature published a paper on Late-Onset Alzheimer’s Disease (LOAD) from researchers at the MCIN. The paper describes the discovery that, contrary to previous understanding, the first physiological sign of Alzheimer’s disease is a decrease in blood flow in the brain.
LOAD is a complex disease as it is not caused by one neurological mechanism, but is a result of several associated mechanisms in the brain. LOAD is a common cause of dementia in humans, and an understanding of the various mechanisms and their interactions is important to developing treatments.
Further reading can be found here:
McGill Newsroom – “Big Data” study discovers earliest sign of Alzheimer’s
McGill Newsroom – Decoding Connectivity
Alzforum – LOAD of Data Place Vascular Malfunction as Earliest Event in Alzheimer’s
ICI Radio Canada – Le premier signe précurseur de l’alzheimer découvert grâce aux métadonnées (Français)