8-Mar-2017: New paper published by Dr. Y. Iturria-Medina and colleagues

A recent paper entitled “Multifactorial causal model of brain (dis)organization and therapeutic intervention: Application to Alzheimer’s disease” by Dr. Yasser Iturria-Medina and colleagues of the MCIN was published in Science Direct.

1-s2.0-S1053811917301684-fx1In this article, we focus on describing the model and applying it at the population-based level for studying late onset Alzheimer’s disease (LOAD). By interrelating six different neuroimaging modalities and cognitive measurements, this model accurately predicts spatiotemporal alterations in brain amyloid-β (Aβ) burden, glucose metabolism, vascular flow, resting state functional activity, structural properties, and cognitive integrity. The results suggest that a vascular dysregulation may be the most-likely initial pathologic event leading to LOAD.

Highlights include:

  • A multifactorial causal model (MCM) of brain (dis)organization and therapeutic intervention is proposed.
  • Prediction of complex multifactorial alterations in Alzheimer’s disease, using six different neuroimaging modalities and the MCM.
  • Identification of potential triggering pathological events and associated “epicenter” brain regions.
  • Identification and characterization of direct multifactorial interactions, vulnerability, and influence level of each biological factor.
  • Identification of optimum therapeutic strategies to stop/reverse disease.

Read the full paper HERE